8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Sep 5th 2026
ReturnsSun, Sep 13th 2026
Nights8
Departing PortSt Louis
Ports of CallSt Louis, Mississippi River, Hannibal, Cruising the River, Muscatine, Dubuque, Winona, Red Wing, Minneapolis/St. Paul
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis… 
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14 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Sep 12th 2026
ReturnsSat, Sep 26th 2026
Nights14
Departing PortMinneapolis/St. Paul
Ports of CallMinneapolis/St. Paul, Red Wing, La Crosse, Dubuque, Davenport, Fort Madison, Hannibal, St Louis, Mississippi River, Memphis, Mississippi River, Vicksburg, Natchez, Baton Rouge, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
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Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Sep 12th 2026
ReturnsSun, Sep 20th 2026
Nights8
Departing PortMinneapolis/St. Paul
Ports of CallMinneapolis/St. Paul, Mississippi River, La Crosse, Cruising the River, Dubuque, Davenport, Hannibal, St Louis (2 Days)
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
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Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Sep 19th 2026
ReturnsSun, Sep 27th 2026
Nights8
Departing PortSt Louis
Ports of CallSt Louis, Mississippi River, Hannibal, Cruising the River, Muscatine, Dubuque, Winona, Red Wing, Minneapolis/St. Paul
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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7 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Sep 26th 2026
ReturnsSat, Oct 3rd 2026
Nights7
Departing PortNew Orleans
Ports of CallNew Orleans, Oak Alley, Baton Rouge, St. Francisville, Natchez, Vicksburg, Mississippi River, Memphis
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
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Ocean View
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Balcony
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Suite
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15 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Sep 26th 2026
ReturnsSun, Oct 11th 2026
Nights15
Departing PortMinneapolis/St. Paul
Ports of CallMinneapolis/St. Paul, Mississippi River, La Crosse, Dubuque, Davenport, Cruising the River, Hannibal, Cruising the River, St Louis, Memphis, Tunica, Cruising the River, Vicksburg, Natchez, Baton Rouge, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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Prices are per person, double occupancy, cruise only and on select sailings. Prices shown are for stateroom categories as noted and are shown in US Dollars. Pricing listed includes taxes and fees. Airfare is not included. Prices and itineraries are based on availability and are subject to change without notice.
